On-hit
Constant DPS against resistant targets.
57.6%
Core
Alternatives
Runes
Precision + Resolve, keystone Lethal Tempo.
Spells
Flash + Exhaust
Skill order
Q > W > E > Q > Q > R > Q > W > Q > W > R > W > W

Champion build
Ranked build for Vayne: core items, alternatives, runes, spells and skill order from analyzed matches.
Constant DPS against resistant targets.
Precision + Resolve, keystone Lethal Tempo.
Flash + Exhaust
Q > W > E > Q > Q > R > Q > W > Q > W > R > W > W
AD scaling and high DPS in extended fights.